The rapid increase in use of electronic-cigarettes (e-cigarettes), especially among youth, raises the urgency for regulating bodies to make informed decisions, guidance, and policy on these products. This study evaluated cardiac function in an experimental model following exposure to e-cigarettes..... [Read more..]
Electronic cigarettes (e-cigs) are devices designed to deliver nicotine in a vaping solution rather than smoke and without tobacco combustion. Perceived as a safer alternative to conventional cigarettes, e-cigs are aggressively marketed as lifestyle-choice consumables, thanks to few restrictions and a lack of regulatory guidelines... [Read more..]
At a gas station just across the river from Harvard Square, a bright yellow billboard trumpets “E-Cig and Vaping Specialists.” Advertisements for all of the major e-cigarette brands are plastered on the walls of the station and even the gas pumps. Prominently displayed inside behind the counter, e-cig brands Blu and Njoy—in regular, menthol, cherry, and vanilla flavors... [Read more..]
Nicotinic acetylcholine receptors, or nAChRs, form the basis of nicotine addiction. The ⍺4β2⍺5 nAChR is the focus of this study. When an individual uses, either a cigarette or an e-cigarette, nicotine is released, rapidly moving from the bloodstream to the brain. There it binds to the nAChRs and results in the opening of the receptor, sodium, and calcium enter into the receptor and potassium exits. The effect of calcium entering releases the neurotransmitter dopamine. Once this transmitter is released the user experiences a pleasurable feeling... [Read more..]
Designed and implemented an independent study examining e-cigarette vapor’s effects on cellular stress pathways. Used several cell-based assays to monitor stress pathway activation; demonstrated that exposure to vapor condensates induces the xenobiotic response in human lung epithelial cells.